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These immune stimulatory factors function as damage-associated molecular patterns, which can transcriptionally activate pro-inflammatory cytokines (TNF-, IL-1, IL-6 and IL-10) and chemokines (MCP-1, MIP-2 and IL-8) [25], [51], [68]

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Juan Bao for assistance in molecular cloning, the staff members of the Large-scale Protein Preparation System at the National Facility for Protein Science in Shanghai (NFPS), Zhangjiang Lab for equipment maintenance and management, and staff scientists at BL18U1 and BL19U1 beamlines of NFPS at Shanghai Synchrotron Radiation Facility, for assistance during data collection

For example, depsipeptides made with Ser or Thr linked to the peptide backbone via an ester bond can function as peptide switches